Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21250634 | 0.89 | ALDH1A1 (0.50) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| SCHEMBL29116748 | 0.88 | ALDH1A1 (0.56) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Phenylacetic Acid SCHEMBL10524553 | 0.88 | AKR1B1 (0.71) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Ether SCHEMBL28095799 | 0.86 | CES1 (0.50) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Alcohol SCHEMBL10996109 | 0.85 | CES1 (0.58) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Methyl Alcohol SCHEMBL11054071 | 0.84 | CES1 (0.64) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| SCHEMBL77563 | 0.84 | CES1 (0.70) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| SCHEMBL28519984 | 0.84 | L3MBTL1 (0.50) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Propionic Acid SCHEMBL28008519 | 0.83 | AKR1B1 (0.62) | CES1CES2AKR1B1ALDH1A1L3MBTL1 | |
| Ether SCHEMBL9242996 | 0.82 | MAPT (0.58) | CES1CES2AKR1B1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |