Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | UTRN | P46939 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820132 | 0.83 | MAPT (0.60) | MAPTTP53SMN1; SMN2UTRNHDAC6 | |
| SCHEMBL5638115 | 0.79 | MAPT (0.70) | MAPTTP53SMN1; SMN2UTRNHTR2B | |
| SCHEMBL9820155 | 0.79 | MAPT (0.56) | MAPTTP53SMN1; SMN2UTRNHTR2B | |
| SCHEMBL9289255 | 0.78 | MAPT (0.56) | MAPTTP53SMN1; SMN2UTRNHTR2B | |
| SCHEMBL19405977 | 0.78 | HDAC6 (0.63) | MAPTTP53SMN1; SMN2UTRNHDAC6 | |
| SCHEMBL1675515 | 0.78 | MAPT (0.65) | MAPTTP53SMN1; SMN2HDAC6KDM4E | |
| SCHEMBL9514445 | 0.78 | MAPT (0.65) | MAPTTP53SMN1; SMN2HDAC6KDM4E | |
| SCHEMBL9141441 | 0.76 | MAPT (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1TDP1 | |
| SCHEMBL19029271 | 0.75 | HDAC6 (0.81) | MAPTHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL32663685 | 0.74 | MAPT (0.54) | MAPTTP53SMN1; SMN2POLBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182061-B1 | NEW PROCESS FOR PREPARING 2(4-FLUOROPHENYL) ALPHA METHYL-5-BENZOXAZOLE ACETIC ACID | RAVIZZA S.p.A. (IT) | 1991-12-27 | — | — | EP | claimed |
| US-4652654-A | Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid | RAVIZZA SPA (IT) | 1987-03-24 | — | — | US | claimed |
| EP-0182061-A1 | New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid | RAVIZZA S.p.A. (IT) | 1986-05-28 | — | — | EP | claimed |
| EP-0182061-B1 | NEW PROCESS FOR PREPARING 2(4-FLUOROPHENYL) ALPHA METHYL-5-BENZOXAZOLE ACETIC ACID | RAVIZZA S.p.A. (IT) | 1991-12-27 | — | — | EP | disclosed |
| US-4652654-A | Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid | RAVIZZA SPA (IT) | 1987-03-24 | — | — | US | disclosed |
| US-4652654-A | Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid | RAVIZZA SPA (IT) | 1987-03-24 | — | — | US | disclosed |
| EP-0182061-A1 | New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid | RAVIZZA S.p.A. (IT) | 1986-05-28 | — | — | EP | disclosed |
| EP-0182061-A1 | New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid | RAVIZZA S.p.A. (IT) | 1986-05-28 | — | — | EP | disclosed |