Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820246 | 0.90 | KMT2A (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15019155 | 0.85 | MAPT (0.40) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9820263 | 0.79 | NPC1 (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2GSK3A | |
| SCHEMBL9820261 | 0.77 | MAPT (0.50) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10581570 | 0.76 | MAPT (0.44) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9820242 | 0.76 | TDP1 (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10580319 | 0.75 | MAPT (0.58) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10859854 | 0.73 | MAPT (0.56) | ALDH1A1NR1I2AHRGSK3AGSK3B | |
| SCHEMBL10861754 | 0.73 | MAPT (0.56) | KMT2AMEN1ALDH1A1SMN1; SMN2NR1I2 | |
| SCHEMBL30046270 | 0.73 | LMNA (0.54) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303826-B1 | SUBSTITUTED 2-NITRO METAPHENYLENE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN DYEING KERATINOUS FIBRES AND ESPECIALLY HUMAN HAIR | L'OREAL (FR) | 1991-02-27 | — | — | EP | claimed |
| US-4863482-A | FROM A TRIHALONITROBENZENE | L'OREAL (FR) | 1989-09-05 | — | — | US | claimed |
| EP-0303826-A1 | Substituted 2-nitro metaphenylene diamines, process for their preparation and their use in dyeing keratinous fibres and especially human hair | L'OREAL (FR) | 1989-02-22 | — | — | EP | claimed |
| EP-0303826-B1 | SUBSTITUTED 2-NITRO METAPHENYLENE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN DYEING KERATINOUS FIBRES AND ESPECIALLY HUMAN HAIR | L'OREAL (FR) | 1991-02-27 | — | — | EP | disclosed |
| US-4863482-A | FROM A TRIHALONITROBENZENE | L'OREAL (FR) | 1989-09-05 | — | — | US | disclosed |
| EP-0303826-A1 | Substituted 2-nitro metaphenylene diamines, process for their preparation and their use in dyeing keratinous fibres and especially human hair | L'OREAL (FR) | 1989-02-22 | — | — | EP | disclosed |