⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820328 | 0.81 | — | — | |
| SCHEMBL31314 | 0.74 | — | — | |
| SCHEMBL2282940 | 0.67 | — | — | |
| SCHEMBL30807 | 0.67 | — | — | |
| SCHEMBL12817498 | 0.65 | — | — | |
| SCHEMBL1973309 | 0.65 | — | — | |
| SCHEMBL9820378 | 0.62 | — | — | |
| SCHEMBL3029034 | 0.60 | — | — | |
| SCHEMBL24597227 | 0.59 | — | — | |
| SCHEMBL64228 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197888-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2024-06-20 | — | — | US | claimed |
| EP-0260042-B1 | 2-(1-OXO-1-IMINO-1-THIACYCLOALKYL)-THIOPENEM DERIVATIVES | PFIZER INC. (US) | 1991-12-27 | — | — | EP | claimed |
| EP-0260042-A1 | 2-(1-Oxo-1-imino-1-thiacycloalkyl)-Thiopenem derivatives | PFIZER INC. (US) | 1988-03-16 | — | — | EP | claimed |
| US-20240197888-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2024-06-20 | — | — | US | disclosed |
| CN-116969944-A | Ethylamino-substituted tricyclic heterocyclic compounds and compositions, formulations and uses thereof | 北京福元医药股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-115536660-A | Benzylamino-substituted heteropolycyclic compounds, compositions, formulations and uses thereof | 北京福元医药股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-11040981-B2 | Pyrrolotriazine compounds and methods of inhibiting TAM kinases | SYROS PHARMACEUTICALS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20210147431-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS INC (US) | 2021-05-20 | — | — | US | disclosed |
| CN-112368285-A | Pyrrolotriazine compounds and methods of inhibiting TAM kinase | 希洛斯医药品股份有限公司 | 2021-02-12 | — | — | CN | disclosed |
| US-20200317676-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS, INC. (US) | 2020-10-08 | — | — | US | disclosed |
| EP-3423446-B1 | NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS | Bayer Pharma AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| EP-3694860-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | Syros Pharmaceuticals, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |
| US-10435396-B2 | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs | BAYER PHARMA AKTIEGESELLSCHAFT (DE) | 2019-10-08 | — | — | US | disclosed |
| WO-2019074962-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS, INC. (US) | 2019-04-18 | — | — | WO | disclosed |
| US-20190071432-A1 | NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-03-07 | — | — | US | disclosed |
| EP-0260042-B1 | 2-(1-OXO-1-IMINO-1-THIACYCLOALKYL)-THIOPENEM DERIVATIVES | PFIZER INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0260042-A1 | 2-(1-Oxo-1-imino-1-thiacycloalkyl)-Thiopenem derivatives | PFIZER INC. (US) | 1988-03-16 | — | — | EP | disclosed |