Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12360483 | 0.83 | NPC1 (0.63) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL14452782 | 0.83 | KDM4E (0.66) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL14557097 | 0.82 | NPC1 (0.48) | RAB9ANPC1NOTUMKDM4EMAPT | |
| SCHEMBL25184601 | 0.81 | NPC1 (0.57) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL21776988 | 0.81 | RAB9A (0.57) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL27418746 | 0.81 | RAB9A (0.64) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL31043550 | 0.81 | NPC1 (0.57) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL6296345 | 0.80 | NPC1 (0.55) | RAB9ANPC1NOTUMKDM4ENPSR1 | |
| SCHEMBL12360712 | 0.79 | NPC1 (0.62) | RAB9ANPC1HTTNOTUMKDM4E | |
| SCHEMBL28640053 | 0.78 | NOTUM (0.53) | RAB9ANPC1NOTUMHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217747-B1 | NEMATOCIDAL AGENTS | CIBA-GEIGY AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| US-4694014-A | 1,3,4-THIADIAZOLES | CIBA-GEIGY CORPORATION (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0217747-A2 | Nematocidal agents | CIBA-GEIGY AG (CH) | 1987-04-08 | — | — | EP | disclosed |