Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18528795 | 0.86 | NPC1 (0.69) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL21434662 | 0.86 | NPC1 (0.47) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL25101279 | 0.81 | NPC1 (0.42) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL414994 | 0.81 | NPC1 (0.64) | NPC1KDM4EALDH1A1POLBRAB9A | |
| SCHEMBL9820533 | 0.80 | RAB9A (0.57) | NPC1KDM4EHSD17B10RAB9ASMN1; SMN2 | |
| SCHEMBL22116712 | 0.79 | NPC1 (0.57) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL5754354 | 0.79 | KDM4E (0.71) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL29121393 | 0.79 | NPC1 (0.71) | NPC1KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL19558149 | 0.79 | NPC1 (0.72) | NPC1KDM4EPOLBHSD17B10RAB9A | |
| SCHEMBL21777008 | 0.78 | KDM4E (0.62) | NPC1KDM4EALDH1A1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| WO-2019195641-A2 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | WO | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| EP-2922857-B1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2018-01-03 | — | — | EP | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-6908937-B2 | Heterocyclic fluoroalkenyl thioethers (II) | BAYER CROPSCIENCE AG (DE) | 2005-06-21 | — | — | US | disclosed |
| US-20030207869-A1 | Heterocyclic fluoroalkenyl thioethers (II) | BAYER CROPSCIENCE AG (DE) | 2003-11-06 | — | — | US | disclosed |
| US-6605631-B1 | Controlling fungi and pests; improved activity and plant tolerability | BASF AKTIENGESELLSCHAFT (DE) | 2003-08-12 | — | — | US | disclosed |
| EP-1303500-A1 | HETEROCYCLIC FLUOROALKENYL THIOETHERS (II) | Bayer Aktiengesellschaft (DE) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006256-A1 | HETEROCYCLIC FLUOROALKENYL THIOETHERS (II) | BAYER CROPSCIENCE AG (DE) | 2002-01-24 | — | — | WO | disclosed |
| US-6031110-A | Ortho-substituted 2-methoxyiminophenyl-N-methylacetamides | BASF AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| EP-0686152-B1 | ORTHO-SUBSTITUTED 2-METHOXYIMINOPHENYLACETIC ACID METHYLAMIDES | BASF AG (DE) | 1997-05-02 | — | — | EP | disclosed |
| EP-0757042-A1 | Ortho-substituted 2-methoxyiminophenylaceticacid methylester | BASF Aktiengesellschaft (DE) | 1997-02-05 | — | — | EP | disclosed |
| EP-0686152-A1 | ORTHO-SUBSTITUTED 2-METHOXYIMINOPHENYLACETIC ACID METHYLAMIDES | BASF AG (DE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019331-A1 | ORTHO-SUBSTITUTED 2-METHOXYIMINOPHENYLACETIC ACID METHYLAMIDES | BASF AKTIENGESELLSCHAFT (DE) | 1994-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207869-A1 | Heterocyclic fluoroalkenyl thioethers (II) | CYP2E1, CYP2S1, CYP1A1 | NPC1 3368/4885KDM4E 2355/4885ALDH1A1 602/4885 |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | RHOXF2, BPTF, SREBF1 | NPC1 480/4885KDM4E 1414/4885ALDH1A1 2056/4885 |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | RHOXF2, BPTF, SREBF1 | NPC1 480/4885KDM4E 1414/4885ALDH1A1 2056/4885 |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K1, MAP3K6, MAP3K20 | NPC1 2721/4885KDM4E 1100/4885ALDH1A1 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.