Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.60 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28280920 | 0.89 | CYP2D6 (0.64) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL3334971 | 0.81 | CYP2D6 (0.48) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7097730 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL8983562 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL8983627 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL23850144 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL30364156 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL31046801 | 0.81 | CYP2D6 (0.83) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL20191913 | 0.79 | CYP2D6 (0.79) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 | |
| SCHEMBL2631769 | 0.79 | CYP2D6 (0.79) | CYP2D6MC4RKCNH2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017724-A | Antihypoxic, CNS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0267024-B1 | HYDROFLUORENE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |