Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30785090 | 1.00 | KDM4E (0.55) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4113759 | 0.86 | MAPT (0.61) | KDM4ERAB9APDE4BPDE4DALDH1A1 | |
| SCHEMBL30785070 | 0.86 | KDM4E (0.46) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9820662 | 0.85 | KDM4E (0.56) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11346572 | 0.82 | ALDH1A1 (0.47) | KDM4ENPC1RAB9APDE4BPDE4D | |
| SCHEMBL7419064 | 0.82 | CA12 (0.54) | KDM4ENPC1RAB9APDE4BPDE4D | |
| SCHEMBL6269698 | 0.81 | SLC6A9 (0.62) | KDM4EPDE4BPDE4DALDH1A1MAPT | |
| SCHEMBL3895445 | 0.81 | SRC (0.70) | — | |
| SCHEMBL4129937 | 0.80 | MAPT (0.55) | KDM4ERAB9AALDH1A1LMNAMAPT | |
| SCHEMBL1342546 | 0.79 | KMT2A (0.47) | KMT2AMEN1NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017724-A | Antihypoxic, CNS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0267024-B1 | HYDROFLUORENE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |
| EP-0267024-A2 | Hydrofluorene derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-05-11 | — | — | EP | disclosed |