Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.41 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35294 | 1.00 | NOS1 (0.41) | NOS1NOS2NOS3ALDH1A1 | |
| SCHEMBL8090 | 0.97 | — | — | |
| SCHEMBL9045714 | 0.97 | — | — | |
| SCHEMBL9045708 | 0.97 | — | — | |
| SCHEMBL9048924 | 0.97 | — | — | |
| SCHEMBL5473839 | 0.94 | ALDH1A1 (0.41) | NOS1NOS2NOS3ALDH1A1 | |
| SCHEMBL19332 | 0.92 | — | — | |
| SCHEMBL9045789 | 0.92 | — | — | |
| SCHEMBL9047282 | 0.92 | — | — | |
| SCHEMBL6470302 | 0.89 | NOS1 (0.41) | NOS1NOS2NOS3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820695-A | GRAMNEGATIVE BACTERIA | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | claimed |
| EP-0124216-B1 | C-20- AND C-23-MODIFIED MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | claimed |
| EP-0103465-B1 | 20-AMINO MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1986-09-10 | — | — | EP | claimed |
| EP-0124216-A1 | C-20- and C-23-modified macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-11-07 | — | — | EP | claimed |
| US-4468511-A | C-20- And C-23-Modified macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | claimed |
| EP-0103465-A1 | 20-Amino macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-03-21 | — | — | EP | claimed |
| EP-0240264-B1 | IMPROVED PROCESS FOR PREPARING MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1991-08-28 | — | — | EP | disclosed |
| US-4921947-A | Process for preparing macrolide derivatives | ELI LILLY AND COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4920103-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0188373-B1 | MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1989-11-08 | — | — | EP | disclosed |
| US-4820694-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| US-4820695-A | GRAMNEGATIVE BACTERIA | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0124216-B1 | C-20- AND C-23-MODIFIED MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |
| EP-0188373-A2 | Macrolide derivatives | ELI LILLY AND COMPANY (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0124216-A1 | C-20- and C-23-modified macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-11-07 | — | — | EP | disclosed |
| US-4468511-A | C-20- And C-23-Modified macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | disclosed |
| EP-0103465-A1 | 20-Amino macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4353826-A | ANTITUBERCULAR ANTIBIOTICS | CIBA-GEIGY CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| US-4261891-A | BACTERICIDES, ANTITUBERCULAR AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| US-4005077-A | DERIVATIVES OF RIFAMYCIN S OR SV | CIBA-GEIGY CORPORATION (US) | 1977-01-25 | — | — | US | disclosed |