Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 11/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9821787 | 1.00 | PPARG (0.44) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821791 | 1.00 | PPARG (0.44) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821796 | 0.92 | PPARG (0.54) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821708 | 0.91 | LTB4R (0.42) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821712 | 0.91 | LTB4R (0.42) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821699 | 0.91 | LTB4R (0.42) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821655 | 0.91 | PPARG (0.44) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL10407624 | 0.88 | PPARG (0.53) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL10639132 | 0.85 | PPARG (0.46) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL9821686 | 0.84 | LTB4R (0.44) | LTB4RLTB4R2CYSLTR2CYSLTR1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292977-B1 | ALKOXY-SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATE DERIVATIVES | G.D. Searle & Co. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4889871-A | ANTIINFLAMMATORY AGENTS; SELECTIVE LEUKOTRIENE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0292977-A1 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives | G.D. Searle & Co. (US) | 1988-11-30 | — | — | EP | disclosed |