Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | GFER | P55789 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980150 | 0.89 | ALDH1A1 (0.76) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL984837 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL982608 | 0.86 | POLB (0.52) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL982270 | 0.86 | SMN1; SMN2 (0.52) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL982366 | 0.84 | SMN1; SMN2 (0.68) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL980195 | 0.84 | SMN1; SMN2 (0.68) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL979286 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL984394 | 0.83 | SMN1; SMN2 (0.70) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL981227 | 0.82 | ALDH1A1 (0.65) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL981950 | 0.81 | SMN1; SMN2 (0.64) | ALDH1A1HPGDRAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917248-B1 | 1-ACYLDIHYDROPYRAZOL DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-08-19 | — | — | EP | claimed |
| US-7875644-B2 | tyrosine kinase inhibitors, in particular Met kinase; antitumor agents;1-(Benzo-1,2,5-thiadiazol-5-ylmethylcarbonyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole; leukemia, carcinomas | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | claimed |
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-09 | — | — | US | claimed |
| CN-101243048-A | 1-acyldihydropyrazol derivatives | MERCK PATENT GMBH (DE) | 2008-08-13 | — | — | CN | claimed |
| EP-1917248-B1 | 1-ACYLDIHYDROPYRAZOL DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MET, FLT3, ERBB3 | ALDH1A1 399/4885HPGD 2204/4885RAB9A 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.