Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655319 | 0.82 | HRH3 (0.41) | ALDH1A1HRH3TSHREPHX1GAA | |
| SCHEMBL5503198 | 0.80 | HRH3 (0.39) | HRH3TSHREPHX1GAASMN1; SMN2 | |
| SCHEMBL7451255 | 0.80 | HRH3 (0.43) | ALDH1A1HRH3TSHREPHX1GAA | |
| SCHEMBL4800510 | 0.80 | PLA2G2C (0.40) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL4803328 | 0.80 | PLA2G2C (0.40) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL13506436 | 0.79 | HRH3 (0.46) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL13387471 | 0.79 | HRH3 (0.46) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL4808486 | 0.79 | EPHX2 (0.41) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL9822641 | 0.79 | HRH3 (0.39) | HRH3TSHREPHX1GAAEPHX2 | |
| SCHEMBL8325170 | 0.78 | HRH3 (0.44) | HRH3TSHREPHX1GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |