Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800510 | 1.00 | PLA2G2C (0.40) | PLA2G2CHRH3EPHX2TSHRACE | |
| SCHEMBL4808486 | 0.89 | EPHX2 (0.41) | HRH3EPHX2TSHRACEACE2 | |
| SCHEMBL3655319 | 0.87 | HRH3 (0.41) | HRH3EPHX2TSHRACEACE2 | |
| SCHEMBL5503198 | 0.85 | HRH3 (0.39) | HRH3TSHRACEACE2EPHX1 | |
| SCHEMBL8303908 | 0.80 | HRH3 (0.43) | HRH3EPHX2TSHREPHX1MAPT | |
| SCHEMBL2456561 | 0.80 | EPHX1 (0.39) | HRH3ACEACE2EPHX1SMN1; SMN2 | |
| SCHEMBL9822667 | 0.80 | ALDH1A1 (0.41) | HRH3EPHX2TSHREPHX1MAPT | |
| SCHEMBL13506436 | 0.79 | HRH3 (0.46) | HRH3EPHX2TSHREPHX1MAPT | |
| SCHEMBL13387471 | 0.79 | HRH3 (0.46) | HRH3EPHX2TSHREPHX1MAPT | |
| SCHEMBL5594884 | 0.79 | NAAA (0.43) | PLA2G2CACEACE2EPHX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966198-A1 | 2-AMINO-3,4-DIHYDRO-PYRIDOÝ3,4-D¨PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007050612-A1 | 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |