Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655319 | 0.99 | HRH3 (0.41) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2456561 | 0.94 | EPHX1 (0.39) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL16461184 | 0.88 | SMN1; SMN2 (0.39) | GAAMAPK1HTTSMN1; SMN2ACE | |
| SCHEMBL4800510 | 0.85 | PLA2G2C (0.40) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL4803328 | 0.85 | PLA2G2C (0.40) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL1067615 | 0.81 | RAB9A (0.39) | SMN1; SMN2ACEACE2EPHX1 | |
| SCHEMBL9822667 | 0.80 | ALDH1A1 (0.41) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL23160898 | 0.80 | HRH3 (0.40) | HRH3GAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL8586951 | 0.80 | CTSK (0.43) | MAPK1SMN1; SMN2ACEACE2TSHR | |
| SCHEMBL13387471 | 0.80 | HRH3 (0.46) | HRH3GAAMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791837-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029862-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |