Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.73 |
| ▸ | HPGD | P15428 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL18340669 | 0.96 | KDM4E (0.80) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL980589 | 0.89 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL11342550 | 0.88 | KDM4E (0.73) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL6249450 | 0.87 | KDM4E (0.95) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL27502941 | 0.86 | KDM4E (0.77) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL299753 | 0.85 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL3399561 | 0.85 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL5142971 | 0.85 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL1932763 | 0.85 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 | |
| Salicylic Acid SCHEMBL217212 | 0.85 | KDM4E (0.91) | KDM4EHPGDALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031328-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD (US) | 2014-01-30 | — | — | US | claimed |
| US-20110021484-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD | 2011-01-27 | — | — | US | claimed |
| EP-2262509-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | Bernstein, Lawrence (US) | 2010-12-22 | — | — | EP | claimed |
| WO-2009111681-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | BERNSTEIN LAWRENCE (US) | 2009-09-11 | — | — | WO | claimed |
| US-20140031328-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD (US) | 2014-01-30 | — | — | US | disclosed |
| US-20110021484-A1 | Gallium compounds and methods of use to treat inflammatory bowel disease | BERNSTEIN LAWRENCE RICHARD | 2011-01-27 | — | — | US | disclosed |
| EP-2262509-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | Bernstein, Lawrence (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009111681-A2 | GALLIUM COMPOUNDS AND METHODS OF USE TO TREAT INFLAMMATORY BOWEL DISEASE | BERNSTEIN LAWRENCE (US) | 2009-09-11 | — | — | WO | disclosed |
| EP-1857460-A2 | New metal complexes, method of preparing them and therapeutic uses for them | SOCIETE DE COORDINATION DE RECHERCHES THERAPEUTIQUES (FR) | 2007-11-21 | — | — | EP | disclosed |