Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876692 | 0.69 | ALDH1A1 (0.47) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL309794 | 0.69 | MAPT (0.50) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL25873873 | 0.69 | MEN1 (0.45) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL10596267 | 0.69 | MAPT (0.40) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL1600165 | 0.68 | ALDH1A1 (0.35) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL1773148 | 0.67 | MEN1 (0.40) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL16306321 | 0.67 | MEN1 (0.46) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL14576557 | 0.65 | MEN1 (0.41) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL3462381 | 0.65 | MEN1 (0.41) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL11162416 | 0.64 | MEN1 (0.44) | MEN1KMT2AUSP2PPARGKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107311945-A | Thiosemicarbazones part and preparation method thereof, thiosemicarbazones metal complex and preparation method thereof | 河南理工大学 | 2017-11-03 | — | — | CN | claimed |
| CN-107311945-A | Thiosemicarbazones part and preparation method thereof, thiosemicarbazones metal complex and preparation method thereof | 河南理工大学 | 2017-11-03 | — | — | CN | disclosed |
| CN-107311945-A | Thiosemicarbazones part and preparation method thereof, thiosemicarbazones metal complex and preparation method thereof | 河南理工大学 | 2017-11-03 | — | — | CN | disclosed |
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |
| EP-0288898-A1 | Substituted chinoxalyl-imidazolidine-2,4-diones, process for their preparation, their use as medicaments and pharmacological preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-02 | — | — | EP | disclosed |