Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823025 | 0.82 | NPC1 (0.75) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL24920215 | 0.78 | NPC1 (0.54) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL26260604 | 0.77 | NPC1 (0.62) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL16644147 | 0.75 | NPC1 (0.55) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL24920314 | 0.75 | NPC1 (0.51) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9694252 | 0.74 | KDM4E (0.44) | NPC1MEN1RAB9AKMT2AMAPT | |
| SCHEMBL1781479 | 0.74 | SMN1; SMN2 (0.55) | NPC1RAB9AALDH1A1HPGDLMNA | |
| SCHEMBL9822779 | 0.73 | TDP1 (0.72) | NPC1MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL18083009 | 0.73 | NQO2 (0.47) | KMT2AALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL18082993 | 0.73 | NQO2 (0.47) | KMT2AALDH1A1MAPTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |