Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998880 | 0.93 | FDPS (0.44) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| SCHEMBL13961615 | 0.89 | CYP2D6 (0.43) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8902556 | 0.87 | GNAO1 (0.41) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| SCHEMBL11190349 | 0.86 | CYP2D6 (0.48) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| SCHEMBL20633400 | 0.84 | CYP2D6 (0.40) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11185659 | 0.84 | CYP2D6 (0.47) | FDPSCYP2D6KMT2AMEN1ALDH1A1 | |
| SCHEMBL14083904 | 0.77 | — | — | |
| SCHEMBL551922 | 0.75 | — | — | |
| SCHEMBL7282339 | 0.75 | — | — | |
| SCHEMBL6781145 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231139-B1 | DIHYDROBENZOFURANE AND CHROMANE CARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEUROLEPTICS | Laboratoires DELAGRANGE (FR) | 1991-12-04 | — | — | EP | disclosed |
| EP-0231139-A2 | Dihydrobenzofurane and chromane carboxamide derivatives, processes for their preparation and their use as neuroleptics | Laboratoires DELAGRANGE (FR) | 1987-08-05 | — | — | EP | disclosed |