Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | FABP6 | P51161 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196669 | 0.86 | RAB9A (0.61) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8764992 | 0.83 | RAB9A (0.58) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9823073 | 0.82 | RAB9A (0.71) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL31133324 | 0.82 | TDP1 (1.00) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4348032 | 0.82 | TDP1 (1.00) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL10435576 | 0.81 | ALDH1A1 (0.76) | ALDH1A1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9822779 | 0.78 | TDP1 (0.72) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL16927680 | 0.77 | ALDH1A1 (0.72) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL10435158 | 0.77 | ALDH1A1 (0.81) | ALDH1A1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL19622430 | 0.77 | TDP1 (0.70) | TDP1ALDH1A1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |