Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823559 | 0.88 | IRAK4 (0.46) | IRAK4POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9823416 | 0.86 | IRAK4 (0.51) | IRAK4MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL9823609 | 0.85 | IRAK4 (0.50) | IRAK4MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL9823630 | 0.85 | IRAK4 (0.50) | IRAK4MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL9823479 | 0.85 | TLR7 (0.61) | IRAK4POLBKMT2AALDH1A1NPC1 | |
| SCHEMBL9823455 | 0.84 | IRAK4 (0.59) | IRAK4ALDH1A1NPC1HPGDTLR7 | |
| SCHEMBL9823363 | 0.83 | IRAK4 (0.48) | IRAK4CYP1A1CYP1B1POLBNPC1 | |
| SCHEMBL9823391 | 0.81 | TLR7 (0.48) | IRAK4ALDH1A1TLR7MAPT | |
| Monoethanolamine SCHEMBL10552824 | 0.79 | TLR7 (0.54) | IRAK4POLBRXFP1KMT2ACYP1A2 | |
| SCHEMBL9823191 | 0.78 | IRAK4 (0.42) | IRAK4NPSR1TLR7MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |