Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823363 | 0.87 | IRAK4 (0.48) | TLR7IRAK4CHEK1GAAMAPT | |
| SCHEMBL9823479 | 0.83 | TLR7 (0.61) | TLR7IRAK4ALDH1A1CHEK1GAA | |
| SCHEMBL9823416 | 0.82 | IRAK4 (0.51) | TLR7IRAK4ALDH1A1CHEK1 | |
| SCHEMBL9823183 | 0.81 | IRAK4 (0.52) | TLR7IRAK4ALDH1A1MAPT | |
| SCHEMBL9823455 | 0.81 | IRAK4 (0.59) | TLR7HDAC1IRAK4ALDH1A1MAPT | |
| SCHEMBL9823799 | 0.81 | RAB9A (0.61) | TLR7HDAC1HDAC8HDAC6IRAK4 | |
| SCHEMBL9823609 | 0.81 | IRAK4 (0.50) | TLR7IRAK4ALDH1A1CHEK1 | |
| SCHEMBL9823630 | 0.81 | IRAK4 (0.50) | TLR7IRAK4ALDH1A1CHEK1 | |
| SCHEMBL9832252 | 0.80 | MAPT (0.43) | ALDH1A1MAPT | |
| SCHEMBL9831306 | 0.80 | MAPT (0.49) | EGFRHDAC3HDAC1HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |