Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823416 | 0.99 | IRAK4 (0.51) | IRAK4KDM4ERAB9ANPC1TLR7 | |
| SCHEMBL9823630 | 0.98 | IRAK4 (0.50) | IRAK4KDM4ERAB9ANPC1TLR7 | |
| SCHEMBL9823191 | 0.88 | IRAK4 (0.42) | IRAK4TLR7TSHRMAOAACHE | |
| SCHEMBL9823183 | 0.85 | IRAK4 (0.52) | IRAK4KDM4ERAB9ANPC1TLR7 | |
| SCHEMBL9823503 | 0.84 | IRAK4 (0.48) | IRAK4TLR7HPGDACHETDP1 | |
| SCHEMBL9823239 | 0.84 | TDP1 (0.44) | IRAK4TLR7ACHECHEK1TDP1 | |
| SCHEMBL10553815 | 0.84 | PTGER1 (0.50) | TLR7TDP1 | |
| SCHEMBL9823490 | 0.83 | CNR2 (0.42) | IRAK4KDM4ETLR7HSD17B10PDE4B | |
| SCHEMBL9823137 | 0.83 | HTR2B (0.53) | IRAK4KDM4ERAB9ANPC1TLR7 | |
| SCHEMBL9823486 | 0.82 | HTR2B (0.52) | IRAK4KDM4ERAB9ANPC1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |