Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL10552508 | 0.93 | HDAC6 (0.56) | HDAC6HDAC1HDAC8PIM1IRAK4 | |
| SCHEMBL9823432 | 0.84 | TLR7 (0.50) | PIM1TLR7 | |
| SCHEMBL10625332 | 0.81 | NPC1 (0.50) | HDAC6HDAC1HDAC8NPC1RAB9A | |
| SCHEMBL9823539 | 0.81 | MAPT (0.60) | HDAC6HDAC1HDAC8IRAK4TLR7 | |
| SCHEMBL9823593 | 0.81 | IRAK4 (0.66) | HDAC6IRAK4TLR7NPC1RAB9A | |
| SCHEMBL2553430 | 0.77 | HDAC6 (0.77) | HDAC6HDAC1HDAC8PIM1IRAK4 | |
| SCHEMBL9823605 | 0.77 | MAPT (0.41) | PIM1IRAK4TLR7NPC1RAB9A | |
| SCHEMBL9823477 | 0.77 | TDP1 (0.64) | HDAC6HDAC1HDAC8IRAK4TLR7 | |
| SCHEMBL9823352 | 0.76 | TDP1 (0.42) | HDAC6HDAC1HDAC8IRAK4TLR7 | |
| SCHEMBL9823592 | 0.76 | MEN1 (0.48) | HDAC6HDAC1HDAC8IRAK4TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |