Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | NPY1R | P25929 | 1/20 | 0.58 |
| ▸ | NPY2R | P49146 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823539 | 0.91 | MAPT (0.60) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823214 | 0.89 | TLR7 (0.49) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823541 | 0.89 | RAB9A (0.61) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823593 | 0.88 | IRAK4 (0.66) | TLR7HDAC6MAPTATMIRAK4 | |
| SCHEMBL9823799 | 0.88 | RAB9A (0.61) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823543 | 0.86 | IRAK4 (0.57) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823137 | 0.85 | HTR2B (0.53) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823576 | 0.85 | LMNA (0.50) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823285 | 0.85 | RAB9A (0.50) | TDP1TLR7HDAC1HDAC8HDAC6 | |
| SCHEMBL9823479 | 0.85 | TLR7 (0.61) | TDP1TLR7MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |