Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823477 | 0.88 | TDP1 (0.64) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823539 | 0.87 | MAPT (0.60) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823214 | 0.82 | TLR7 (0.49) | HDAC6NPC1RAB9ATLR7MAPK1 | |
| SCHEMBL9823541 | 0.82 | RAB9A (0.61) | HDAC6NPC1RAB9ATLR7MAPK1 | |
| SCHEMBL9823592 | 0.82 | MEN1 (0.48) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823543 | 0.82 | IRAK4 (0.57) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823799 | 0.81 | RAB9A (0.61) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823600 | 0.81 | HDAC6 (0.64) | IRAK4HDAC6NPC1RAB9ATLR7 | |
| SCHEMBL9823502 | 0.80 | TLR7 (0.65) | IRAK4TLR7MAPK1ATMGAA | |
| SCHEMBL9823455 | 0.80 | IRAK4 (0.59) | IRAK4NPC1RAB9ATLR7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262873-B1 | N-TETRAZOLYL THIAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-21 | — | — | EP | disclosed |
| US-4879295-A | ANTIALLERGENS | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-07 | — | — | US | disclosed |
| EP-0262873-A1 | N-tetrazolyl thiazolecarboxamide derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |