Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27464065 | 0.98 | CYP11B1 (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL10940691 | 0.73 | CYP11B2 (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL7095208 | 0.69 | CYP11B1 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL2806313 | 0.69 | CYP11B1 (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL12094093 | 0.67 | HSP90AA1 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL7094263 | 0.67 | CYP11B1 (0.45) | CYP11B1CYP11B2 | |
| Quinoline SCHEMBL28305101 | 0.67 | ALDH1A1 (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL30848588 | 0.66 | KDM4E (0.33) | — | |
| SCHEMBL7096288 | 0.66 | CYP11B1 (0.37) | CYP11B1CYP11B2 | |
| SCHEMBL7093600 | 0.66 | CYP11B1 (0.41) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0160502-B1 | Improvements in and relating to octahydrothiazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0160502-A2 | Improvements in and relating to octahydrothiazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1985-11-06 | — | — | EP | disclosed |