Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 4/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824478 | 0.95 | GNAO1 (0.46) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL9824777 | 0.89 | GNAO1 (0.44) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL9824411 | 0.84 | GNAO1 (0.43) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL598617 | 0.83 | GNAO1 (0.58) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL9824415 | 0.82 | SIGMAR1 (0.44) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL20374733 | 0.82 | GNAO1 (0.60) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL24207822 | 0.79 | GNAO1 (0.53) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL9825562 | 0.79 | GNAO1 (0.43) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL9823981 | 0.78 | GNAO1 (0.40) | GNAO1GNAI3GNAI1PRMT3CARM1 | |
| SCHEMBL25433756 | 0.78 | GNAO1 (0.54) | GNAO1GNAI3GNAI1HRH3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |