Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825263 | 0.95 | L3MBTL1 (0.47) | L3MBTL1CHRM1POLBPKMTSHR | |
| SCHEMBL9824985 | 0.89 | L3MBTL1 (0.50) | L3MBTL1CHRM1POLBPKMTSHR | |
| SCHEMBL9728131 | 0.81 | CYP1A2 (0.51) | CHRM1POLBHRH3CYP1A2MAPK1 | |
| SCHEMBL22266184 | 0.79 | CHRM5 (0.53) | L3MBTL1POLBPKMTSHRSMN1; SMN2 | |
| SCHEMBL9824301 | 0.79 | HRH3 (0.48) | CHRM1HRH3SIGMAR1ACHE | |
| SCHEMBL5337084 | 0.78 | CHRM1 (0.48) | CHRM1POLBPKMTSHRHRH3 | |
| SCHEMBL12130736 | 0.76 | HRH3 (0.58) | HRH3CYP1A2SIGMAR1CHRM5 | |
| SCHEMBL1031783 | 0.76 | KDM4E (0.60) | L3MBTL1POLBPKMTSHRCYP1A2 | |
| SCHEMBL63826 | 0.76 | KDM4E (0.60) | L3MBTL1POLBPKMTSHRCYP1A2 | |
| SCHEMBL828920 | 0.75 | CHRM1 (0.52) | L3MBTL1CHRM1SIGMAR1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |