SCHEMBL9728131

SCHEMBL9728131

O=C(O)CN1CCC(CCCN2CCCCC2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
MAPK1 P28482 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
SIGMAR1 Q99720 1/20 0.41
HRH3 Q9Y5N1 4/20 0.40
ACHE P22303 1/20 0.40
GAA P10253 1/20 0.38
ALDH1A1 P00352 1/20 0.38
POLB P06746 1/20 0.38
MAPT P10636 1/20 0.38
CHRM1 P11229 2/20 0.38
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
HTR1A P08908 1/20 0.38
CHRM5 P08912 1/20 0.38
ADRA2A P08913 1/20 0.38
DRD2 P14416 1/20 0.38
ADRA2B P18089 1/20 0.38
CHRM3 P20309 1/20 0.38
DRD4 P21917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9825263 0.86 L3MBTL1 (0.47) CYP1A2MAPK1SMN1; SMN2SIGMAR1HRH3
SCHEMBL9824090 0.81 L3MBTL1 (0.46) CYP1A2MAPK1SMN1; SMN2SIGMAR1HRH3
SCHEMBL8053644 0.80 HRH3 (0.50) CYP1A2MAPK1SMN1; SMN2HRH3ACHE
SCHEMBL24754066 0.78 MAPT (0.47) CYP1A2HRH3POLBMAPTCHRM1
SCHEMBL6069474 0.77 PKM (0.47) POLBMAPTCHRM1CHRM2CHRM4
SCHEMBL30115021 0.77 HRH3 (0.54) CYP1A2SIGMAR1HRH3CHRM5
SCHEMBL30115019 0.77 HRH3 (0.54) CYP1A2SIGMAR1HRH3CHRM5
SCHEMBL15150 0.76 GAA (0.58) CYP1A2MAPK1SMN1; SMN2GAAALDH1A1
SCHEMBL10942934 0.76 GAA (0.58) CYP1A2MAPK1SMN1; SMN2GAAALDH1A1
SCHEMBL9174370 0.76 GAA (0.58) CYP1A2MAPK1SMN1; SMN2GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5175158-A CONDENSED DIAZEPINONES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS DR. KARL THOMAE, GMBH (DE) 1992-12-29 US disclosed