Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824803 | 0.86 | KDM4E (0.43) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9825145 | 0.83 | MEN1 (0.43) | STAT3ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL9824934 | 0.81 | ALOX5 (0.38) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9824628 | 0.81 | KMT2A (0.47) | KDM4EALDH1A1KMT2AMEN1GAA | |
| SCHEMBL9824096 | 0.77 | KDM4E (0.43) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9824389 | 0.77 | STAT3 (0.44) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9824444 | 0.76 | ALDH1A1 (0.47) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9824142 | 0.76 | MEN1 (0.46) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9824403 | 0.75 | MEN1 (0.45) | STAT3KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1570874 | 0.75 | ALDH1A1 (0.47) | KDM4EALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |