Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10767733 | 0.90 | KMT2A (0.46) | KMT2AMEN1LMNAALDH1A1DRD3 | |
| SCHEMBL9824744 | 0.89 | LMNA (0.55) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9823980 | 0.84 | KDM4E (0.42) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9824813 | 0.83 | ALK (0.43) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9824004 | 0.83 | TOP1 (0.43) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9824515 | 0.83 | HPGD (0.35) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL10771643 | 0.82 | LMNA (0.37) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9824932 | 0.81 | DRD3 (0.50) | KMT2AMEN1LMNAALDH1A1DRD3 | |
| SCHEMBL9824143 | 0.81 | ALK (0.39) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL9824797 | 0.81 | TNKS (0.39) | KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |