Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823988 | 0.86 | KMT2A (0.44) | KMT2AKDM4EMEN1PKMALDH1A1 | |
| SCHEMBL9824096 | 0.74 | KDM4E (0.43) | KMT2AKDM4EMEN1ALOX5ALDH1A1 | |
| SCHEMBL10385637 | 0.71 | ALDH1A1 (0.52) | KMT2AKDM4EMEN1PKMALDH1A1 | |
| SCHEMBL9824803 | 0.71 | KDM4E (0.43) | KMT2AKDM4EMEN1ALOX5ALDH1A1 | |
| SCHEMBL9824468 | 0.71 | ENPP2 (0.42) | KDM4EALOX5ALDH1A1HPGDALOX15 | |
| SCHEMBL9209414 | 0.71 | GRK6 (0.39) | KMT2AMEN1ALOX5ENPP2SMN1; SMN2 | |
| SCHEMBL10577525 | 0.71 | GAA (0.41) | KMT2AKDM4EMEN1ALOX5ALDH1A1 | |
| SCHEMBL9824589 | 0.70 | KDM4E (0.40) | KDM4EALDH1A1HPGDALOX15TSHR | |
| SCHEMBL10576893 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1HPGDALOX15TSHR | |
| SCHEMBL10575865 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1HPGDALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4880814-A | 7-cycloalkyl naphthyridines | ABBOTT LABORATORIES (US) | 1989-11-14 | — | — | US | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |