SCHEMBL9824581

SCHEMBL9824581

CCOC(=O)c1cc(NC(=S)N2CCCCN2)c(F)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
KMT2A Q03164 3/20 0.41
KDM4E B2RXH2 3/20 0.40
TDP1 Q9NUW8 3/20 0.40
RAB9A P51151 1/20 0.39
MAPK1 P28482 2/20 0.39
MAP2K2 P36507 1/20 0.38
MAP2K1 Q02750 1/20 0.38
MEN1 O00255 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
LMNA P02545 1/20 0.37
NPSR1 Q6W5P4 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CREBBP Q92793 1/20 0.35
HSD17B10 Q99714 1/20 0.35
WDR5 P61964 1/20 0.35
TP53 P04637 1/20 0.35
HTT P42858 1/20 0.35
POLB P06746 1/20 0.35
JMJD6 Q6NYC1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9764390 0.91 ALDH1A1 (0.44) ALDH1A1KMT2AKDM4ETDP1RAB9A
SCHEMBL9824017 0.85 ALDH1A1 (0.36) ALDH1A1KDM4ELMNAWDR5
SCHEMBL9824910 0.83 ALDH1A1 (0.47) ALDH1A1KMT2AKDM4ETDP1RAB9A
SCHEMBL9824287 0.77 GAA (0.37) ALDH1A1KMT2AKDM4ETDP1MEN1
SCHEMBL9491717 0.76 ABCC1 (0.39) ALDH1A1KMT2AKDM4ERAB9AMEN1
SCHEMBL9419236 0.73 RAB9A (0.35) KDM4ERAB9ALMNASMN1; SMN2HTT
SCHEMBL9824718 0.71 NPSR1 (0.35) ALDH1A1KMT2ATDP1MAPK1MEN1
SCHEMBL7164662 0.70
SCHEMBL9434432 0.70 NPSR1 (0.31) NPSR1POLB
SCHEMBL13190095 0.70 ALDH1A1 (0.46) ALDH1A1KDM4ETDP1MAP2K2MAP2K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273417-B1 THIADIAZABICYCLONONANE DERIVATIVES AND HERBICIDAL COMPOSITIONS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1991-08-21 EP disclosed
US-4885023-A EFFECTIVE IN LOW DOSE AGAINST PADDY FIELD, UPLAND FIELD AND PERENNIAL WEEDS; NONPHYTOTOXIC KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1989-12-05 US disclosed
EP-0273417-A1 Thiadiazabicyclononane derivatives and herbicidal compositions KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1988-07-06 EP disclosed