Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824506 | 0.90 | ALDH1A1 (0.38) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9824874 | 0.90 | ALDH1A1 (0.38) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9825033 | 0.90 | KDM4E (0.43) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9825282 | 0.85 | PIM1 (0.50) | TOP2AALDH1A1TOP2BPIM1GSK3A | |
| SCHEMBL10667865 | 0.82 | PIM1 (0.46) | TOP2AKDM4EALDH1A1TOP2BPIM1 | |
| SCHEMBL9824513 | 0.82 | ALDH1A1 (0.40) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9824623 | 0.81 | KDM4E (0.52) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9824167 | 0.81 | CYP1A2 (0.39) | TOP2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9206941 | 0.80 | IKBKB (0.56) | PIM1GSK3AIKBKBAURKACHUK | |
| SCHEMBL9839287 | 0.80 | KDM4E (0.45) | TOP2AKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |