Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824706 | 1.00 | S1PR1 (0.35) | S1PR1S1PR3S1PR5CARM1PRMT6 | |
| SCHEMBL9824543 | 0.83 | GNAI3 (0.33) | — | |
| SCHEMBL9824547 | 0.83 | GNAI3 (0.33) | — | |
| SCHEMBL9824151 | 0.78 | ALDH1A1 (0.40) | TSHRALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9824159 | 0.78 | ALDH1A1 (0.40) | TSHRALDH1A1HTTMEN1KMT2A | |
| SCHEMBL9824700 | 0.76 | S1PR1 (0.34) | S1PR1S1PR3S1PR5CARM1PRMT6 | |
| SCHEMBL16373740 | 0.76 | CARM1 (0.44) | S1PR1S1PR3S1PR5CARM1PRMT6 | |
| SCHEMBL9824794 | 0.75 | TDP1 (0.34) | TSHRALDH1A1SIGMAR1HTTL3MBTL1 | |
| SCHEMBL9824788 | 0.75 | TDP1 (0.34) | TSHRALDH1A1SIGMAR1HTTL3MBTL1 | |
| SCHEMBL9824830 | 0.73 | GNAI3 (0.36) | S1PR1S1PR3S1PR5TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |