Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824457 | 1.00 | CHRM5 (0.53) | CHRM5ADRA2CACHESMN1; SMN2MAOB | |
| SCHEMBL9824611 | 0.93 | CHRM5 (0.48) | CHRM5ADRA2CACHESMN1; SMN2DRD2 | |
| SCHEMBL9824792 | 0.83 | MAOB (0.39) | CHRM5ADRA2CMAOBKDM2BHRH3 | |
| SCHEMBL3599101 | 0.82 | CCR2 (0.42) | CHRM5ADRA2CSMN1; SMN2KDM2BCCR2 | |
| SCHEMBL3599106 | 0.82 | CCR2 (0.42) | CHRM5ADRA2CSMN1; SMN2KDM2BCCR2 | |
| SCHEMBL9824677 | 0.80 | MAPT (0.43) | CHRM5ADRA2CMAOBHRH3MAPT | |
| SCHEMBL4387050 | 0.80 | KDM2B (0.38) | CHRM5ADRA2CMAOBDRD2DRD3 | |
| SCHEMBL3897140 | 0.80 | CYP2D6 (0.44) | CHRM5ADRA2CMAOBDRD2KDM2B | |
| SCHEMBL665119 | 0.80 | MAOB (0.38) | CHRM5ADRA2CMAOBDRD2DRD3 | |
| SCHEMBL13036986 | 0.80 | KDM2B (0.38) | CHRM5ADRA2CMAOBDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |