Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.33 |
| ▸ | KHK | P50053 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824747 | 0.85 | KMT2A (0.49) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL9824797 | 0.85 | TNKS (0.39) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9824035 | 0.83 | KDM4E (0.39) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL9824254 | 0.83 | KMT2A (0.34) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9823980 | 0.82 | KDM4E (0.42) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL9824600 | 0.76 | KCNH2 (0.36) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| Hydrochloric Acid SCHEMBL10766907 | 0.75 | KMT2A (0.58) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL10669165 | 0.75 | EPHA2 (0.45) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL10577440 | 0.73 | PDE7A (0.34) | HPGD | |
| SCHEMBL9824114 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |