Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824309 | 0.85 | HSD17B10 (0.42) | PIM1GSK3APIM3PRKD3PIM2 | |
| SCHEMBL9825057 | 0.85 | PRKD3 (0.48) | PIM1GSK3APIM3PRKD3GSK3B | |
| SCHEMBL9824649 | 0.84 | PIM1 (0.45) | PIM1GSK3APIM3GSK3BTOP1 | |
| SCHEMBL9824932 | 0.83 | DRD3 (0.50) | PIM1GSK3APIM3PIM2KDM4E | |
| SCHEMBL9824158 | 0.83 | ALDH1A1 (0.52) | PIM1GSK3APIM3PIM2KDM4E | |
| SCHEMBL9824004 | 0.81 | TOP1 (0.43) | PIM1GSK3APIM3PRKD3GSK3B | |
| SCHEMBL9824535 | 0.81 | KMT2A (0.45) | PIM1GSK3APIM3GSK3BDYRK1A | |
| SCHEMBL9824748 | 0.81 | ALDH1A1 (0.49) | PIM1GSK3APIM3GSK3BTOP1 | |
| SCHEMBL9824093 | 0.81 | PRKD3 (0.47) | PIM1GSK3APIM3PRKD3GSK3B | |
| SCHEMBL10768783 | 0.80 | PIM1 (0.40) | PIM1PIM3TOP1PIM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |