Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MATK | P42679 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824074 | 0.85 | KMT2A (0.46) | KMT2AHRH4PIM3RPS6KB1MATK | |
| SCHEMBL10770013 | 0.85 | LMNA (0.43) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9825107 | 0.84 | LMNA (0.53) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824232 | 0.84 | LMNA (0.42) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9824649 | 0.82 | PIM1 (0.45) | PIM3PIM1GSK3ACHRM2GSK3B | |
| SCHEMBL9824747 | 0.82 | KMT2A (0.49) | KMT2ALMNAHRH4PIM3RPS6KB1 | |
| SCHEMBL9824429 | 0.82 | KMT2A (0.45) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| SCHEMBL9824920 | 0.81 | PIM1 (0.45) | KMT2ALMNAPIM3DYRK1APIM1 | |
| Hydrochloric Acid SCHEMBL10766907 | 0.81 | KMT2A (0.58) | KMT2ALMNAHRH4MAT2ADPP4 | |
| SCHEMBL10576387 | 0.80 | PIM1 (0.35) | PIM3KDM1APIM1GSK3APIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |