Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824201 | 1.00 | CHRM5 (0.55) | CHRM5ADRA2CACHEALOX15SMN1; SMN2 | |
| SCHEMBL9824407 | 0.93 | CHRM5 (0.50) | CHRM5ADRA2CACHEALOX15SMN1; SMN2 | |
| SCHEMBL9824505 | 0.84 | ALOX15 (0.41) | CHRM5ADRA2CALOX15HRH3CARM1 | |
| SCHEMBL8372524 | 0.81 | CHRM5 (0.55) | CHRM5ADRA2CACHE | |
| SCHEMBL11615967 | 0.81 | ALOX15 (0.41) | CHRM5ADRA2CALOX15KDM4ECARM1 | |
| SCHEMBL9824888 | 0.81 | HRH3 (0.41) | CHRM5ADRA2CALOX15HRH3 | |
| SCHEMBL3897612 | 0.79 | CYP2D6 (0.45) | ALOX15KDM4ECARM1PRMT6PRMT3 | |
| SCHEMBL10064309 | 0.79 | CYP2D6 (0.45) | ALOX15KDM4ECARM1PRMT6PRMT3 | |
| SCHEMBL7797268 | 0.79 | CHRM5 (0.52) | CHRM5ADRA2CACHESMN1; SMN2KDM4E | |
| SCHEMBL22953689 | 0.79 | CHRM5 (0.61) | CHRM5ADRA2CACHESMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |