Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ADH5 | P11766 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825326 | 0.84 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10736484 | 0.79 | PDE3B (0.52) | PDE3BPDE3ACRBNTBXAS1CYP19A1 | |
| SCHEMBL7268192 | 0.76 | CYP3A4 (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9381030 | 0.75 | PDE3B (1.00) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL28274911 | 0.75 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL7288894 | 0.74 | PDE3B (0.58) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL7273296 | 0.74 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL7266092 | 0.74 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8881314 | 0.73 | PDE3B (0.46) | PDE3BPDE3ACRBNTBXAS1HTR2A | |
| SCHEMBL8881958 | 0.71 | PDE3B (0.48) | PDE3BPDE3ACRBNTBXAS1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247724-B1 | THIADIAZINON DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-11 | — | — | EP | claimed |
| EP-0247724-A1 | Thiadiazinon derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-12-02 | — | — | EP | claimed |
| EP-0247724-B1 | THIADIAZINON DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-4861773-A | Heterocyclic compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-08-29 | — | — | US | disclosed |
| WO-1989003832-A1 | THERAPEUTICALLY ACTIVE CONDENSED THIADIAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-05 | — | — | WO | disclosed |