Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.60 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ADH5 | P11766 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28274911 | 0.89 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL10463333 | 0.75 | PDE3B (1.00) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9825522 | 0.74 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9825326 | 0.74 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL2437598 | 0.74 | CASP1 (0.49) | CYP11B1CYP11B2CYP1A2MKNK1MKNK2 | |
| SCHEMBL2813793 | 0.74 | PSEN1 (0.53) | CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3290710 | 0.73 | CYP1A2 (0.44) | CYP11B1CYP11B2CYP1A2MKNK1LMNA | |
| SCHEMBL16097172 | 0.73 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL20777317 | 0.72 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL30800784 | 0.72 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662971-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1998-05-13 | — | — | EP | disclosed |
| US-5677306-A | ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS | RHONE-POULENC RORER S.A. (FR) | 1997-10-14 | — | — | US | disclosed |
| EP-0662971-A1 | DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007893-A1 | DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1994-04-14 | — | — | WO | disclosed |
| EP-0247724-B1 | THIADIAZINON DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-4861773-A | Heterocyclic compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-08-29 | — | — | US | disclosed |
| WO-1989003832-A1 | THERAPEUTICALLY ACTIVE CONDENSED THIADIAZINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-05 | — | — | WO | disclosed |
| EP-0314400-A1 | Therapeutically active condensed thiadiazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-03 | — | — | EP | disclosed |
| EP-0247724-A1 | Thiadiazinon derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-12-02 | — | — | EP | disclosed |