Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424635 | 0.77 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| SCHEMBL9520079 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| SCHEMBL20678819 | 0.68 | TSHR (0.53) | ALDH1A1TSHRTP53TET2ACLY | |
| SCHEMBL1524780 | 0.66 | — | — | |
| SCHEMBL12927538 | 0.66 | CPT2 (0.42) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| Lactic Acid SCHEMBL8947291 | 0.64 | TSHR (0.65) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| SCHEMBL8114552 | 0.64 | ALDH1A1 (0.47) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| SCHEMBL10455605 | 0.62 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTPTGS1TP53 | |
| SCHEMBL61001 | 0.62 | — | — | |
| SCHEMBL3677211 | 0.62 | TSHR (0.39) | ALDH1A1TSHRMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |