Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.57 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.43 |
| ▸ | ITGAV | P06756 | 5/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825943 | 0.93 | TGM2 (0.59) | TGM2CTSLCTSSCYP1A2ITGB3 | |
| SCHEMBL9826397 | 0.91 | TGM2 (0.69) | TGM2CTSLCTSSCYP1A2CTSB | |
| SCHEMBL9825336 | 0.91 | TGM2 (0.69) | TGM2CTSLCTSSCYP1A2CTSB | |
| SCHEMBL9825517 | 0.87 | TGM2 (0.75) | TGM2CTSLCTSSCTSBCTSK | |
| SCHEMBL9826660 | 0.87 | TGM2 (0.49) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL9825279 | 0.86 | TGM2 (0.63) | TGM2CTSLCTSSCYP1A2CTSB | |
| SCHEMBL9827308 | 0.86 | TGM2 (0.63) | TGM2CTSLCTSSCYP1A2CTSB | |
| SCHEMBL9826986 | 0.86 | TGM2 (0.66) | TGM2CTSLCTSSCTSBCTSK | |
| SCHEMBL9825257 | 0.86 | TGM2 (0.61) | TGM2CTSLCTSSCYP1A2CTSB | |
| SCHEMBL9826332 | 0.86 | TGM2 (0.75) | TGM2CTSLCTSSCYP1A2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |