Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 5/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.49 |
| ▸ | ITGAV | P06756 | 12/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825638 | 0.87 | TGM2 (0.57) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL9825176 | 0.86 | TGM2 (0.65) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL9827105 | 0.86 | TGM2 (0.51) | TGM2ITGB3ITGAVITGA2BSIRT2 | |
| SCHEMBL9826151 | 0.85 | TGM2 (0.53) | TGM2ITGB3ITGAVITGA2BSIRT2 | |
| SCHEMBL9826397 | 0.84 | TGM2 (0.69) | TGM2 | |
| SCHEMBL9825336 | 0.84 | TGM2 (0.69) | TGM2 | |
| SCHEMBL9825943 | 0.83 | TGM2 (0.59) | TGM2ITGB3ITGAV | |
| SCHEMBL9826249 | 0.82 | ALDH1A1 (0.46) | TGM2ITGB3ITGAVITGA2B | |
| SCHEMBL9825517 | 0.81 | TGM2 (0.75) | TGM2 | |
| SCHEMBL9826129 | 0.80 | CTSL (0.54) | TGM2ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |