Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.40 |
| ▸ | CDC25B | P30305 | 4/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | CDC25A | P30304 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934723 | 0.87 | TGM2 (0.55) | KMT2AMEN1ATMTGM2PTPN1 | |
| SCHEMBL5362012 | 0.87 | TGM2 (0.55) | KMT2AMEN1ATMTGM2PTPN1 | |
| SCHEMBL9825717 | 0.86 | KMT2A (0.45) | KMT2AMEN1ATMTGM2PTPN1 | |
| SCHEMBL9825394 | 0.86 | KMT2A (0.44) | KMT2AMEN1ATMTGM2PTPN1 | |
| SCHEMBL9825801 | 0.84 | TGM2 (0.55) | ALDH1A1KMT2AATMTGM2CTSS | |
| SCHEMBL9826129 | 0.83 | CTSL (0.54) | KMT2AMEN1ATMTGM2CYP1A2 | |
| SCHEMBL9825735 | 0.82 | CTSL (0.56) | KMT2AMEN1ATMTGM2CYP1A2 | |
| SCHEMBL9825276 | 0.79 | TGM2 (0.54) | ATMTGM2CYP1A2CTSS | |
| SCHEMBL9826397 | 0.77 | TGM2 (0.69) | TGM2CYP1A2CTSS | |
| SCHEMBL9825336 | 0.77 | TGM2 (0.69) | TGM2CYP1A2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |