Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.60 |
| ▸ | CTSS | P25774 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | TACR1 | P25103 | 2/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825978 | 0.91 | CTSB (0.60) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL9825813 | 0.91 | CTSL (0.68) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL9826149 | 0.91 | CTSL (0.68) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL9826192 | 0.87 | CTSL (0.63) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL31397580 | 0.85 | CTSL (0.62) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL31397587 | 0.85 | CTSL (0.62) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL31397597 | 0.85 | CTSL (0.62) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL9825481 | 0.85 | HDAC8 (0.62) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL9826741 | 0.85 | CTSL (0.60) | CTSLCTSBCTSSCTSKTACR1 | |
| SCHEMBL10969130 | 0.84 | CTSL (0.65) | CTSLCTSBCTSSCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |