Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.63 |
| ▸ | CASP1 | P29466 | 10/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGAV | P06756 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825458 | 0.93 | TGM2 (0.61) | TGM2CYP1A2ITGB3ITGAV | |
| SCHEMBL4936394 | 0.91 | TGM2 (0.75) | TGM2 | |
| SCHEMBL9825343 | 0.91 | TGM2 (0.75) | TGM2 | |
| SCHEMBL4937443 | 0.88 | TGM2 (0.82) | TGM2 | |
| SCHEMBL4935845 | 0.88 | TGM2 (0.73) | TGM2 | |
| SCHEMBL9826409 | 0.87 | TGM2 (0.61) | TGM2CASP1CYP1A2ITGB3ITGAV | |
| SCHEMBL9825601 | 0.87 | TGM2 (0.53) | TGM2CYP1A2ITGB3ITGAV | |
| SCHEMBL9826613 | 0.86 | TGM2 (0.68) | TGM2CYP1A2 | |
| SCHEMBL4656563 | 0.86 | TGM2 (0.66) | TGM2CYP1A2 | |
| SCHEMBL4929775 | 0.86 | TGM2 (0.68) | TGM2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |