Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 8/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 8/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826072 | 0.93 | TGM2 (0.59) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9825092 | 0.92 | TGM2 (0.73) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9826379 | 0.92 | TGM2 (0.73) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9826024 | 0.88 | TGM2 (0.79) | TGM2CTSLCTSBCTSSCTSK | |
| SCHEMBL9825843 | 0.87 | TGM2 (0.64) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9825344 | 0.87 | TGM2 (0.66) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9825817 | 0.87 | TGM2 (0.66) | TGM2CYP1A2CTSLCTSBCTSS | |
| SCHEMBL9826882 | 0.87 | TGM2 (0.69) | TGM2CTSLCTSBCTSSCTSK | |
| SCHEMBL9826302 | 0.87 | TGM2 (0.63) | TGM2CYP1A2CASP1ITGB3ITGAV | |
| SCHEMBL9826416 | 0.86 | TGM2 (0.65) | TGM2CYP1A2CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |