Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sematilide SCHEMBL161098 | 0.90 | ALDH1A1 (0.67) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| Sematilide SCHEMBL122585 | 0.89 | POLB (0.67) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| SCHEMBL10642568 | 0.88 | CA1 (0.54) | ALDH1A1KCNH2KDM4EPOLBBLM | |
| Sematilide SCHEMBL9274272 | 0.88 | POLB (0.66) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| SCHEMBL10920006 | 0.86 | KCNH2 (0.60) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| SCHEMBL9826588 | 0.85 | CACNA1F (0.57) | ALDH1A1KCNH2KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL10645163 | 0.85 | KCNH2 (0.61) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| SCHEMBL9628220 | 0.84 | HPGD (0.58) | ALDH1A1KCNH2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10643150 | 0.84 | OPRK1 (0.66) | ALDH1A1NFKB1KCNH2KDM4EPOLB | |
| SCHEMBL10645045 | 0.84 | SMN1; SMN2 (0.57) | ALDH1A1NFKB1KCNH2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285284-B1 | N-PHENETHYLAMINOALKYL-BENZAMIDE ANTI-ARRHYTHMIA AGENTS | Pfizer Limited (GB) | 1991-05-15 | — | — | EP | disclosed |